Links Between Hormones and Cancer

The market for cancer therapeutics is huge and growing by double-digits annually. This phenomenal growth is fueled especially in the area of biologic drugs. Globally, more than 10 million people are affected by cancer annually, a number that is expected to increase 2.4 percent each year through 2020 up to 14 million. Common cancers include breast, bladder, cervical colon/rectum, esophageal, liver, lung, prostate and stomach cancer.

Among the key trends of current cancer therapies including chemotherapy and biotherapeutics, is hormone therapy. Much research is needed but in a July 9, 2008 www.BreastCancer.org article, we learn some of the details about how estrogen and progesterone play roles in the development of certain breast cancers.

T.S Wiley has long believed that hormone therapy could affect breast cancer, and she touched upon it in her book Sex, Lies, and Menopause.

The article details how estrogen sends signals through the hormone receptors that tell breast cancer cells to grow, and when estrogen attaches to the receptors, they grow and multiply. Once breast cancer is removed, the cells are tested to see if they have hormone receptors, and if either estrogen or progesterone receptors are present, a response to hormonal therapy is very possible. The more estrogen or progesterone receptors present on those cells, the more likely that hormonal therapy will work against the particular cancer. If high levels of both estrogen and progesterone receptors are present, an even greater response to hormonal therapy is likely.

Estrogen and progesterone travel through the bloodstream and find their matching receptor sites on both healthy cells and cancer cells. Receptors are protein molecules that rest on the outside or inside of the cells in your body acting like an on–off switch for cell activities. If the right substance comes along that fits into the receptor, much like a key opening a lock, cell activity is unlocked.

It seems that many breast cancers are hormone-dependent—which means that estrogen and progesterone stimulate their growth by "turning on" hormone receptors in the cancer cells. Without these hormones, the cancer cells are not stimulated to grow, so they wither up and eventually may die.

Call my office to set up an appointment or email me 815-476-5210 or jones.gretchen@gmail.com

It is my intent to stop Wyeth-Ayerst from destroying the compounding of bio-identical hormones by playing the game by their rules. Many of the doctors I have worked with have shown me the ropes.

Five Easy Pieces
Here’s the plan:

• Step 1: Registering compounding pharmacies across the country to make my invention, the Wiley Protocol®, in a standardized fashion that requires methods, materials, packaging and pricing stabilization overseen by me, T.S.Wiley, under a contractual pretext wherein I drive a revenue stream (you) to them in exchange for doing the job right.
• Step 2: Test quarterly their product and rely on you to report your experiences with them.
• Step 3: Publish our feat of standardization of a compounded product in Pharmacy Journals. Until this is accomplished, the FDA won’t ever take bio-identical hormones seriously.
• Step 4: Once we have enough Registered Pharmacies, each donating 10 prescriptions, we can have a legitimate study of a donated consistent product for the treatment of menopause. The study substance must be donated in the US to comply with NIH regulations. No lone Compounding Pharmacy will ever be able to bear the economic burden of a 5000 to 20,000 woman study. This is the only way I can find to beat the system invented by Big Pharma.
• Step 5: Take some of the money made selling Pharmacies packaging with my name on it, that you look for, and finance the study. (pay for indemnification and blood tests)
  5 Easy Pieces and we own our future.

To be very clear: I’m asking you to go to a physician who will honor your request to get your prescription for the Wiley Protocol® at a Registered Pharmacy. Pharmacies not Registered, will offer you “generics” which cost more and are not standardized. You all must take the exactly same thing in order to ever study the results and report them in a credible way. I’m also asking you to reward the pharmacists who will help us prove our point and to help them prove to Congress that Compounding Pharmacy is capable of self-regulation and should not be shut down for the economic gain of Wyeth.

Bottom Line

We spend billions of dollars on menopause and get almost no benefit and quite often harm for our desperate efforts. I intend this to stop. We deserve decent, deliberate medical care based on scientific premise and investigation, hence Feminist Medicine. We are half of the world and we live at the center of the other half’s universe. We are mothers, sisters, daughters and grandmothers as well as lovers and business partners. We shape and defend the world of men and children. When we feel bad, everyone suffers. – T.S.Wiley

Until we have enough pharmacies to realize our goal, we intend to gather your data soon in this spot on the website using the North American Menopause Society’s Questionnaire for symptoms and registering your blood work results if you defer HIPPA privacy regulations. We are currently reviewing software solutions for sifting the data we can gather to report to medical journals.

Call my office to set up an appointment or email me 815-476-5210 or jones.gretchen@gmail.com